Produkte von Bethyl Laboratories

Bethyl

Auf der texanischen Ranch von Bethyl Labs werden beste polyklonale Antikörper für die klinische und diagnostische Forschung hergestellt. Bethyls Netzwerk mit namhaften Wissenschaftlern identifiziert fortlaufend neue Targets für die zellbiologische Forschung. Daraus entsteht ein Antikörperprogramm, das vergleichbaren Anbietern immer einen Schritt voraus ist. Bethyl Laboratories sind einzigartig in ihrer vollständigen Kontrolle aller Schritte der Antikörperproduktion. Von den veterinären Einrichtungen, über die Entwicklung, Produktion und Validierung in den Laboren konzentriert sich das Team von Bethyl darauf, qualitativ hochwertige Produkte zu liefern. Diese Fokussierung auf Qualität bei jedem einzelnen Schritt und die Integration aller Prozessstufen bedeutet, dass Wissenschaftler sich auf Bethyl-Antikörper verlassen können.

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Anti-c-myc
Anti-c-myc

Artikelnummer: A190-104A

Protein function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes. [The UniProt Consortium]
Schlagworte: Anti-MYC, Anti-bHLHe39, Anti-BHLHE39, Anti-Proto-oncogene c-Myc, Anti-Transcription factor p64, Anti-Myc proto-oncogene...
Anwendung: WB, IP, ICC, ELISA
260,00 €
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Anti-phospho-RPA32 (Ser4/Ser8)
Anti-phospho-RPA32 (Ser4/Ser8)

Artikelnummer: A300-245A-M

Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA...
Schlagworte: Anti-phospho-RPA2, Anti-phospho-REPA2, Anti-phospho-RP-A p34, Anti-phospho-RP-A p32, Anti-phospho-RF-A protein 2,...
Anwendung: WB, IP, IHC, ICC/IF
Reaktivität: Human, Mouse
ab 131,00 €
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Anti-DDB1
Anti-DDB1

Artikelnummer: A300-462A

Protein function: Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex...
Schlagworte: Anti-XPCe, Anti-DDB1, Anti-DDBa, Anti-XAP1, Anti-XAP-1, Anti-XPE-BF, Anti-UV-DDB 1, Anti-DDB p127 subunit,...
Anwendung: WB, IP, IHC
Reaktivität: Human, Mouse
ab 131,00 €
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Anti-ASH2
Anti-ASH2

Artikelnummer: A300-489A

Protein function: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone...
Schlagworte: Anti-ASH2L, Anti-ASH2L1, Anti-ASH2-like protein, Anti-Set1/Ash2 histone methyltransferase complex subunit ASH2
Anwendung: WB, IP, IHC, ChIP, ChIP-chip
Reaktivität: Human
465,00 €
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Anti-KIAA0310
Anti-KIAA0310

Artikelnummer: A300-648A

Protein function: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic...
Schlagworte: Anti-SEC16A, Anti-KIAA0310, Anti-SEC16 homolog A, Anti-Protein transport protein Sec16A
Anwendung: WB, IP
Reaktivität: Human
ab 131,00 €
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Anti-NELFE
Anti-NELFE

Artikelnummer: A301-913A

Protein function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. [The UniProt...
Schlagworte: Anti-RD, Anti-NELFE, Anti-NELF-E, Anti-RNA-binding protein RD, Anti-Negative elongation factor E
Anwendung: WB, IP
Reaktivität: Human
ab 131,00 €
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Anti-SHANK3
Anti-SHANK3

Artikelnummer: A304-178A

Protein function: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via...
Schlagworte: Anti-Shank3, Anti-SHANK3, Anti-ProSAP2, Anti-KIAA1650, Anti-Proline-rich synapse-associated protein 2, Anti-SH3 and...
Anwendung: WB, IP
Reaktivität: Human, Mouse
ab 131,00 €
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Anti-ZNF451
Anti-ZNF451

Artikelnummer: A305-177A

Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required...
Schlagworte: Anti-ZNF451, Anti-Zinc finger protein 451, Anti-E3 SUMO-protein ligase ZNF451, Anti-Coactivator for steroid receptors
Anwendung: WB, IP
Reaktivität: Human
ab 131,00 €
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Anti-phospho-Histone H3 (Ser10) (IHC)
Anti-phospho-Histone H3 (Ser10) (IHC)

Artikelnummer: IHC-00061

Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA...
Schlagworte: Anti-phospho-H3FL, Anti-phospho-H3FF, Anti-phospho-H3FK, Anti-phospho-H3FI, Anti-phospho-H3FB, Anti-phospho-H3FD,...
Anwendung: IHC, ICC/IF
Reaktivität: Human, Mouse
ab 131,00 €
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Anti-p73
Anti-p73

Artikelnummer: A300-126A

Protein function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. [The UniProt Consortium]
Schlagworte: Anti-P73, Anti-TP73, Anti-Tumor protein p73, Anti-p53-related protein, Anti-p53-like transcription factor
Anwendung: WB, IP
Reaktivität: Human
ab 131,00 €
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Anti-RbBP5
Anti-RbBP5

Artikelnummer: A300-109A

Protein function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or...
Schlagworte: Anti-RBQ3, Anti-RBBP5, Anti-RBBP-5, Anti-Retinoblastoma-binding protein 5, Anti-Retinoblastoma-binding protein RBQ-3
Anwendung: WB, IP, IHC, ICC, ChIP, ChIP-chip
Reaktivität: Human
ab 131,00 €
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Anti-HdmX/MDM4
Anti-HdmX/MDM4

Artikelnummer: A300-287A

Protein function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium]
Schlagworte: Anti-MDM4, Anti-MDMX, Anti-Protein Mdm4, Anti-Protein Mdmx, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,...
Anwendung: WB, IP
Reaktivität: Human
ab 131,00 €
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