Hexarelin

Hexarelin is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R). It selectively binds to GHS-R over CD36 (IC50s = 15.9 and 2,080 nM, respectively). Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats. It also improves left ventricular function and reduces fibrosis in a mouse model of myocardial ischemia induced by transient ligation of the left descending coronary artery (LAD) when administered at a dose of 0.3 mg/kg per day.Formal Name: L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide. CAS Number: 140703-51-1. Synonyms: Examorelin, H-2-Me-WAWFK, His-2-Me-Trp-Ala-Trp-Phe-Lys-NH2, His-(D)-Mrp-Ala-Trp-(D)-Phe-Lys-NH2. Molecular Formula: C47H58N12O6. Formula Weight: 887.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 221 nm. SMILES: O=C(N[C@H](CC1=C(C)NC2=C1C=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)[C@@H](N)CC6=CN=CN6. InChi Code: InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2,1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59,65)/t28-,35-,38-,39+,40-,41+/m0/s1. InChi Key: RVWNMGKSNGWLOL-GIIHNPQRSA-N.