Zu "K04284" wurden 47 Artikel gefunden!
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YIL 781
Artikelnummer: Cay45211-10
An antagonist of GHS-Ra (Ki = 0.017 µM), is selective for GHS-Ra over the motilin receptor (Ki = 6 µM) and a panel of 30 receptors and enzymes (Kis = > 10 µM), prevents ghrelin-induced decreases in insulin secretion in glucose-stimulated isolated rat pancreatic islets at concentration of 1 µM, increases plasma...
| Schlagworte: | (S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one |
| Anwendung: | GHS-R1alpha antagonist |
| CAS | 875258-85-8 |
| MW: | 409.51 D |
ab 151,00 €
CHO-K1/GHSR Stable Cell Line
Artikelnummer: GSC-M00189
Recombinant CHO-K1 cells stably overexpress human growth hormone secretagogue receptor (GHSR) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | GHSR, Ghrelin receptor, GH-releasing peptide receptor, Growth hormone secretagogue receptor type 1 |
11.424,00 €
Hexarelin
Artikelnummer: Cay30716-1
Hexarelin is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R). It selectively binds to GHS-R over CD36 (IC50s = 15.9 and 2,080 nM, respectively). Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats. It also improves left ventricular function and...
| Schlagworte: | Examorelin, H-2-Me-WAWFK, His-(D)-Mrp-Ala-Trp-(D)-Phe-Lys-NH2, His-2-Me-Trp-Ala-Trp-Phe-Lys-NH2,... |
| Anwendung: | GHS-R peptide agonist |
| CAS | 140703-51-1 |
| MW: | 887 D |
ab 122,00 €
JMV3002
Artikelnummer: Cay10012699-500
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 µg/kg, JMV3002 inhibits...
| Schlagworte: | N-[(1R)-1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenyylethyl)-4H-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2-pyridinecar... |
| Anwendung: | Ghrelin receptor antagonist |
| CAS | 925239-03-8 |
| MW: | 586.7 D |
ab 89,00 €
GHRP-6 (acetate)
Artikelnummer: Cay27262-5
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren, Cay-18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of...
| Schlagworte: | Hexapeptide-2, Growth Hormone Releasing Peptide 6, HWAWFK-NH2, SKF 110679, U 75799E,... |
| Anwendung: | Synthetic growth hormone, GH secretagogue receptor agonist |
| CAS | 145177-42-0 |
| MW: | 1053.2 D |
ab 122,00 €
PF-05190457
Artikelnummer: Cay40142-5
PF-05190457 is an inverse agonist of the growth hormone secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It selectively binds to GHS-R (Ki = 4.37 nM) over M2 muscarinic acetylcholine receptors (mAChRs, Ki = 1,950 nM) and the serotonin (5-HT) receptor subtype 5-HT2B (IC50 = 3,700 nM)....
| Schlagworte: | 1-[2-[(1R)-2,3-dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thi... |
| Anwendung: | GHS-R inverse agonist |
| CAS | 1334782-79-4 |
| MW: | 512.7 D |
ab 53,00 €
PF-5190457
Artikelnummer: TGM-T16508-5mg
Description: PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36). Target: GHSR. Smiles: Cc1cn2cc(CC(=O)N3CCC4(CN(C4)[C@@H]4CCc5cc(ccc45)-c4cc(C)ncn4)CC3)nc2s1. References: Bhattacharya SK, et al. Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor...
| Schlagworte: | PF-05190457 |
| Anwendung: | GHS-R inverse agonist |
| CAS | 1334782-79-4 |
| MW: | 512.67 D |
ab 30,00 €
Anti-GHSR / Ghrelin Receptor
Artikelnummer: ARG55391.100
Protein function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). [The UniProt...
| Schlagworte: | Anti-GHSR, Anti-GHRP, Anti-GHS-R, Anti-Ghrelin receptor, Anti-GH-releasing peptide receptor, Anti-Growth hormone... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
616,00 €
Human GHSR / Growth hormone secretagogue receptor type 1...
Artikelnummer: G-HUFI00411.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anamorelin
Artikelnummer: Cay24676-10
Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Cay-15072, Cay-24458, Ki = 0.7 nM). It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 =...
| Schlagworte: | RC-1291,... |
| Anwendung: | GHSR/ ghrelin receptor agonist |
| CAS | 249921-19-5 |
| MW: | 546.7 D |
ab 102,00 €
Ibutamoren (mesylate)
Artikelnummer: Cay18003-10
Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHSR). Ibutamoren is an orally-active, non-peptidic agonist of GHSR (Kd = 0.4 nM) and, as a result, is a GH secretagogue. It elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of...
| Schlagworte: | L-163,191, MK-0677,... |
| Anwendung: | Growth hormone releasing factor, ghrelin receptor agonist |
| CAS | 159752-10-0 |
| MW: | 624.8 D |
ab 127,00 €
Capromorelin (tartrate)
Artikelnummer: Cay33488-1
Capromorelin is a growth hormone (GH) secretagogue and an agonist of GH secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor. It stimulates GH release from primary rat pituitary cells with an EC50 value of 3 nM. Capromorelin (0.3, 3, and 30 nM) stimulates intracellular calcium mobilization...
| Schlagworte: | CP 424,391-18, RQ-00000005,... |
| Anwendung: | Growth hormone secretagogue receptor (GHSR) agonist |
| CAS | 193273-69-7 |
| MW: | 655.7 D |
ab 85,00 €