Dihexa

Description: Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV. Target: c-Met/HGFR. Smiles: [C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(NCCCCCC(N)=O)=O)[C@H](CC)C)=O)NC(CCCCC)=O. References: Mccoy A T , Benoist C C , Wright J W , et al. Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents[J]. Journal of Pharmacology and Experimental Therapeutics, 2013, 344(1):141-154.