[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic Polypeptide (human) (acetate)

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide is an agonist of the neuropeptide Y (NPY) receptor Y5. It inhibits cAMP production induced by forskolin (Cay-11018) in HEK293 cells expressing the human Y5 receptor (EC50 = 17 nM). [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide selectively binds to Y5 (IC50 = 0.24 nM in HEK293 cells expressing the human receptor) over Y1, Y2, and Y4 (IC50s = 530, >500, and 51 nM, respectively, in BHK-21 cells expressing the human receptors). In vitro, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide increases VEGF levels, as well as endothelial branch length and the number of branch points, in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. It induces relaxation of vasopressin-precontracted rat mesenteric arteries when used at a concentration of 1 µM. Intracranial administration of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide (0.2 and 2 nmol/animal) increases food intake in rats.Formal Name: glycyl-L-prolyl-L-seryl-L-glutaminyl-L-prolyl-L-threonyl-L-tyrosyl-L-prolylglycyl-L-alpha-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-alpha-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-alanyl-2-methylalanyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide, acetate. Molecular Formula: C183H281N57O54S2 . XC2H4O2. Formula Weight: 4207.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Peptide Sequence: GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2 (X = 2-Aminoisobutyric acid). Solubility: Water: Soluble. SMILES: CC(O)=O.OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC(C(C)(C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CO)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]5N(C([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]6N(C([C@H](CC7=CC=C(O)C=C7)NC([C@H]([C@H](O)C)NC([C@H]8N(C([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H]9N(C(CN)=O)CCC9)=O)=O)=O)CCC8)=O)=O)=O)CCC6)=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O. InChi Code: InChI=1S/C183H281N57O54S2.C2H4O2/c1-15-89(4)141(172(289)228-123(82-136(189)254)163(280)219-115(63-74-296-14)150(267)210-93(8)148(265)236-183(11,12)177(294)232-110(29-20-68-205-182(199)200)155(272)216-111(54-58-132(185)250)156(273)214-108(27-18-66-203-180(195)196)152(269)222-117(144(190)261)76-96-34-44-101(245)45-35-96)233-165(282)121(79-99-40-50-104(248)51-41-99)225-154(271)109(28-19-67-204-181(197)198)213-151(268)107(26-17-65-202-179(193)194)215-160(277)118(75-88(2)3)223-146(263)91(6)209-166(283)126(86-241)230-162(279)120(78-98-38-48-103(247)49-39-98)226-161(278)119(77-97-36-46-102(246)47-37-97)224-153(270)106(25-16-64-201-178(191)192)212-145(262)90(5)207-149(266)114(62-73-295-13)218-157(274)112(55-59-133(186)251)217-158(275)113(57-61-139(257)258)220-170(287)130-32-24-72-240(130)176(293)143(95(10)244)235-147(264)92(7)208-159(276)122(81-135(188)253)227-164(281)124(83-140(259)260)211-137(255)85-206-168(285)128-30-22-70-238(128)175(292)125(80-100-42-52-105(249)53-43-100)229-173(290)142(94(9)243)234-171(288)131-33-23-71-239(131)174(291)116(56-60-134(187)252)221-167(284)127(87-242)231-169(286)129-31-21-69-237(129)138(256)84-184,1-2(3)4/h34-53,88-95,106-131,141-143,241-249H,15-33,54-87,184H2,1-14H3,(H2,185,250)(H2,186,251)(H2,187,252)(H2,188,253)(H2,189,254)(H2,190,261)(H,206,285)(H,207,266)(H,208,276)(H,209,283)(H,210,267)(H,211,255)(H,212,262)(H,213,268)(H,214,273)(H,215,277)(H,216,272)(H,217,275)(H,218,274)(H,219,280)(H,220,287)(H,221,284)(H,222,269)(H,223,263)(H,224,270)(H,225,271)(H,226,278)(H,227,281)(H,228,289)(H,229,290)(H,230,279)(H,231,286)(H,232,294)(H,233,282)(H,234,288)(H,235,264)(H,236,265)(H,257,258)(H,259,260)(H4,191,192,201)(H4,193,194,202)(H4,195,196,203)(H4,197,198,204)(H4,199,200,205),1H3,(H,3,4)/t89-,90-,91-,92-,93-,94+,95+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-,/m0./s1. InChi Key: UEGCMOXRPJTUJG-SJNXXKRRSA-N.