TN-16

TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM). It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Cay-9000760) binding to tubulin. Like colchicine, TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells. TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.Formal Name: 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione. CAS Number: 33016-12-5. Synonyms: NSC 239274. Molecular Formula: C19H18N2O2. Formula Weight: 306.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/mL, DMSO: 20 mg/mL, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 234, 319 nm. SMILES: O=C(/C1=C(C)\NC2=CC=CC=C2)NC(CC3=CC=CC=C3)C1=O. InChi Code: InChI=1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-. InChi Key: KWSXUGYAGMSUTN-LGMDPLHJSA-N.