Zu "K07374" wurden 190 Artikel gefunden!
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Paclitaxel
Artikelnummer: AG-CN2-0045-M025
Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....
| Schlagworte: | Taxol, BMS 181339-01, NSC 125973 |
| Anwendung: | Apoptosis Inducer |
| Wirt: | Taxus brevifolia |
| CAS | 33069-62-4 |
| MW: | 853,9 D |
ab 22,00 €
Mebendazole-d8
Artikelnummer: Cay40232-1
Mebendazole-d8 is intended for use as an internal standard for the quantification of mebendazole (Cay-18872) by GC- or LC-MS. Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic. It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole...
| Schlagworte: | R 17635-d8, methyl-d3 (6-(benzoyl-2,3,4,5,6-d5)-1H-benzo[d]imidazol-2-yl)carbamate |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, anthelmintic, microtubule polymerization inhibitor |
| CAS | 1286787-80-1 |
| MW: | 303.3 D |
328,00 €
Mouse TUBa4A (Tubulin Alpha 4A) ELISA Kit
Artikelnummer: ELK-ELK6809.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TUBa4A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TUBa4A....
| Schlagworte: | Tuba4, Tuba4a, Alpha-tubulin 4, Tubulin alpha-4 chain, Tubulin alpha-4A chain, Alpha-tubulin isotype M-alpha-4 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Anti-alpha-tubulin
Artikelnummer: ELK-EA017.100
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and...
| Schlagworte: | Anti-TUBA1, Anti-TUBA4A, Anti-Alpha-tubulin 1, Anti-Tubulin H2-alpha, Anti-Tubulin alpha-1 chain, Anti-Tubulin alpha-4A... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Paclitaxel
Artikelnummer: Cay10461-5
Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values...
| Schlagworte: | NSC 125973, betaS-(benzoylamino)-alphaR-hydroxy-benzenepropanoic acid,... |
| Anwendung: | Apotosis inducer |
| CAS | 33069-62-4 |
| MW: | 853.9 D |
ab 43,00 €
Anti-Tubulin, alpha
Artikelnummer: 600-401-880
Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]
| Schlagworte: | Anti-TUBA1B, Anti-Tubulin K-alpha-1, Anti-Tubulin alpha-1B chain, Anti-Alpha-tubulin ubiquitous, Anti-Tubulin... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
546,00 €
Docetaxel (hydrate)
Artikelnummer: Cay11637-5
Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel (Cay-10461). It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM). In vivo, docetaxel inhibits tumor growth in several cancer models,...
| Schlagworte: | NSC 628503, RP 56976, Taxotel, (alphaR,betaS)-beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-benzenepropanoic... |
| Anwendung: | Microtubule inhibitor |
| CAS | 700367-34-6 |
| MW: | 807.9 D |
ab 54,00 €
Colchicine
Artikelnummer: Cay9000760-100
Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 µM) that binds to tubulin, which disrupts spindle formation during mitosis. It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity...
| Schlagworte: | N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide |
| Anwendung: | Microtubule polymerization inhibitor |
| CAS | 64-86-8 |
| MW: | 399.4 D |
ab 22,00 €
Nocodazole
Artikelnummer: Cay13857-50
Nocodazole is an antimitotic agent. It increases tubulin GTP hydrolysis four-fold and induces tubulin depolymerization. Nocodazole (4 µg/ml) halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase. It also decreases neuronal mitochondrial transport and density in a transgenic...
| Schlagworte: | NSC 238159, Oncodazole, R 17934, N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester |
| Anwendung: | Microtubule function studies, cell cycle arrest |
| CAS | 31430-18-9 |
| MW: | 301.3 D |
ab 48,00 €
Anti-Detyrosinated Alpha Tubulin, clone RM444
Artikelnummer: NSJ-R20459-0.1ML
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to detyrosinated alpha-Tubulin, a posttranslational modification of alpha-tubulin where the C-terminal tyrosine residue has been cleaved. Protein function: Tubulin is the major constituent of microtubules, a cylinder consisting of...
| Schlagworte: | Anti-TUBA3, Anti-TUBA1A, Detyrosinated Alpha Tubulin Antibody |
| Anwendung: | WB, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
737,00 €
Anti-Delta 2-Alpha-Tubulin / dC2, clone RM447
Artikelnummer: NSJ-R20462-0.1ML
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody specifically reacts to dC2-alpha-Tubulin, a C-terminally trimmed version of alpha-tubulin that lacks a carboxy-terminal glutamyl-tyrosine group. Protein function: Tubulin is the major constituent of microtubules, a cylinder consisting of...
| Schlagworte: | Anti-TUBA3, Anti-TUBA1A, Delta 2-Alpha-Tubulin Antibody / dC2 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
737,00 €
Cucurbitacin B
Artikelnummer: AG-CN2-0472-M001
Off-white powder. Soluble in DMSO. Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation, Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties, Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell...
| Schlagworte: | Cuc B, 1,2-Dihydro-alpha-elaterin, Amarine, NSC 49451, NSC 144154 |
| Anwendung: | Microtubule polymerization inhibitor |
| CAS | 6199-67-3 |
| MW: | 558,7 D |
ab 33,00 €