RMC-4550

RMC-4550 is an inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, IC50 = 1.55 nM). It is selective for SHP-2 over a panel of 14 additional protein phosphatases and a panel of 468 protein kinases at 10 µM. It inhibits tumor ERK phosphorylation in a KYSE-520 human esophageal cancer xenograft model in a dose-dependent manner.Formal Name: 3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-6-(2,3-dichlorophenyl)-5-methyl-2-pyrazinemethanol. CAS Number: 2172651-73-7. Molecular Formula: C21H26Cl2N4O2. Formula Weight: 437.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4([C@H](N)[C@H](C)OC4)CC3)N=C2C)=CC=C1. InChi Code: InChI=1S/C21H26Cl2N4O2/c1-12-18(14-4-3-5-15(22)17(14)23)26-16(10-28)20(25-12)27-8-6-21(7-9-27)11-29-13(2)19(21)24/h3-5,13,19,28H,6-11,24H2,1-2H3/t13-,19+/m0/s1. InChi Key: IKUYEYLZXGGCRD-ORAYPTAESA-N.