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RMC-4550
Artikelnummer: TGM-T16762-100mg
Description: RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM). Target: Phosphatase. Smiles: C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N. References: Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven...
| Anwendung: | SHP-2 inhibitor |
| CAS | 2172651-73-7 |
| MW: | 437.36 D |
ab 57,00 €
RMC-4550
Artikelnummer: Cay31011-1
RMC-4550 is an inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, IC50 = 1.55 nM). It is selective for SHP-2 over a panel of 14 additional protein phosphatases and a panel of 468 protein kinases at 10 µM. It inhibits tumor ERK phosphorylation in a KYSE-520 human esophageal cancer xenograft...
| Schlagworte: | 3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-6-(2,3-dichlorophenyl)-5-methyl-2-pyrazinemethanol |
| Anwendung: | SHP-2 inhibitor |
| CAS | 2172651-73-7 |
| MW: | 437.4 D |
ab 67,00 €
