Zu "K07293" wurden 123 Artikel gefunden!
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Anti-SHP2 / PTPN11, clone 2000000
Artikelnummer: NSJ-RQ4920
0.5mg/ml if reconstituted with 0.2ml sterile DI water. PTPN11 Antibody targets Tyrosine-protein phosphatase non-receptor type 11, also known as SHP2, a cytoplasmic protein tyrosine phosphatase encoded by the PTPN11 gene that plays a central role in intracellular signal transduction. SHP2 is a widely expressed...
| Schlagworte: | Anti-PTPN11, Anti-SH-PTP3, Anti-SH-PTP2, Anti-Protein-tyrosine phosphatase 1D, Anti-Protein-tyrosine phosphatase 2C,... |
| Anwendung: | WB, IHC (paraffin), FC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
SPI 112Me
Artikelnummer: Cay36819-1
A prodrug form of SPI 112, inhibits the PTP activity of SHP-2E76K in TK-1 cells, inhibits Paxillin dephosphorylation, ERK1/2 activation, and cell migration in EGF-stimulated MDA-MB-468 cells at 20 µM. SMILES: COC(C1=CC=CC(N/N=C2C3=CC(S(NCC4=CC=C(C=C4)F)(=O)=O)=CC=C3NC/2=O)=C1)=O. InChi Code:...
| Schlagworte: | 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-benzoic acid,... |
| Anwendung: | SPI 112 prodrug, SHP-2 protein tyrosine phosphatase inhibitor |
| CAS | 1243685-62-2 |
| MW: | 482.49 D |
ab 42,00 €
Anti-Recombinant SH-PTP2, clone 4B5
Artikelnummer: E-AN300806L.100
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2...
| Schlagworte: | Anti-PTPN11, Anti-SH-PTP2, Anti-SH-PTP3, Anti-Protein-tyrosine phosphatase 2C, Anti-Protein-tyrosine phosphatase 1D,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
Anti-SHP2 / PTPN11
Artikelnummer: NSJ-F53772-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP...
| Schlagworte: | Anti-PTPN11, Anti-SH-PTP2, Anti-SH-PTP3, Anti-Protein-tyrosine phosphatase 2C, Anti-Protein-tyrosine phosphatase 1D,... |
| Anwendung: | WB, IHC, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
361,00 €
Anti-SHP2 / PTPN11, clone GBO-16
Artikelnummer: NSJ-RQ8892
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. SHP2 (PTPN11) is a cytoplasmic protein tyrosine phosphatase that plays a central role in multiple signaling pathways, including the RAS/MAPK cascade. It contains two SH2 domains that mediate interactions with phosphorylated proteins and a...
| Schlagworte: | Anti-PTPN11, Anti-SH-PTP2, Anti-SH-PTP3, Anti-Protein-tyrosine phosphatase 2C, Anti-Protein-tyrosine phosphatase 1D,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Homogeneous Full Length SHP-2 Assay Kit
Artikelnummer: BPS-79330
The Homogeneous full length SHP-2 Assay Kit is a complete assay system designed to measure full length SHP-2 activity for screening and profiling applications. Using this kit, only two simple steps on a microtiter plate are needed to analyze the full length SHP-2 activity level. At the first step, the SHP-2 enzyme...
| Schlagworte: | SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433, SH2, SH 2, SH-2, |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
968,00 €
SHP099
Artikelnummer: Cay20000-1
SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM). It stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and...
| Schlagworte: | 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine |
| Anwendung: | SHP2 inhibitor |
| CAS | 1801747-42-1 |
| MW: | 352.3 D |
ab 69,00 €
SHP2 Activating Peptide (IRS1_pY1172(dPEG8)pY1222)
Artikelnummer: BPS-79319-2
IRS1_pY1172(dPEG8)pY1222(SEQ: H2N-LN(pY)IDLDLV(dPEG8)LST(pY) -ASINFQK-amide)
| Schlagworte: | Shp2, PTP2C, SHP-2, PTPN11, PTP-2C, PTP-1D, SH-PTP2, SH-PTP3, Protein-tyrosine phosphatase 1D, Protein-tyrosine... |
| Anwendung: | SHP-2 activator |
| Ursprungsart: | human |
ab 235,00 €
Anti-PTPN11
Artikelnummer: ATA-HPA069674.100
Rabbit Polyclonal PTPN11 Antibody against Human protein tyrosine phosphatase non-receptor type 11. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs:...
| Schlagworte: | Anti-Shp2, Anti-SHP-2, Anti-PTP2C, Anti-PTP-2C, Anti-PTP-1D, Anti-PTPN11, Anti-SH-PTP2, Anti-SH-PTP3,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 264,00 €
NSC 87877
Artikelnummer: Cay14908-10
The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction. NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively). It is much less effective...
| Schlagworte: | 8-hydroxy-7-[2-(6-sulfo-2-naphthalenyl)diazenyl]-5-quinolinesulfonic acid |
| Anwendung: | SHP-1 / SHP-2 inhibitor |
| CAS | 56990-57-9 |
| MW: | 459.4 D |
ab 59,00 €
Anti-PTPN11/Shp2
Artikelnummer: A301-544A
Protein function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). [The...
| Schlagworte: | Anti-Shp2, Anti-PTP2C, Anti-SHP-2, Anti-PTP-2C, Anti-PTPN11, Anti-PTP-1D, Anti-SH-PTP3, Anti-SH-PTP2,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
SHP-2, His-Tag
Artikelnummer: BPS-79018
Human recombinant SHP-2, also known as PTPN11 (protein tyrosine phosphatase N11), catalytic domain, (a.a. 2-593 (end) with N-terminal His-tag, Genbank accession number NM_002834, MW=70 kDa, expressed in an E. coli expression system.
| Schlagworte: | Shp2, PTP2C, SHP-2, PTPN11, PTP-2C, PTP-1D, SH-PTP2, SH-PTP3, Protein-tyrosine phosphatase 1D, Protein-tyrosine... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 70 kD |
581,00 €