MK-3697

MK-3697 is an orexin receptor 2 (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 3,600 nM). MK-3697 decreases active awake time and increases slow wave sleep (SWS) and rapid eye movement (REM) sleep in mice when administered at a dose of 100 mg/kg. It also decreases active awake time and increases phase II SWS in dogs.Formal Name: N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-[2,3'-bipyridine]-4-carboxamide. CAS Number: 1224846-01-8. Molecular Formula: C23H21N5O3S. Formula Weight: 447.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 1 mg/ml. lambdamax: 290, 316 nm. SMILES: O=C(C1=CC(C2=CN=CC(C)=C2)=NC=C1C3=NC=CS3)NCC4=CC=C(OC)C(OC)=N4. InChi Code: InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29). InChi Key: VSOUDUXMPUHJEU-UHFFFAOYSA-N.