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MK-3697
Artikelnummer: LKT-M403007.1
MK-3697 is a selective orexin 2 receptor antagonist. SMILES: CC1=CC(=CN=C1)C2=NC=C(C(=C2)C(=O)NCC3=NC(=C(C=C3)OC)OC)C4=NC=CS4
| Schlagworte: | MK3697, M8238285OA, N-((5,6-dimethoxy-2-pyridinyl)methyl)-5'-methyl-5-(2-thiazolyl)-(2,3'-Bipyridine)-4-carboxamide,... |
| Anwendung: | Orexin 2 receptor antagonist |
| CAS | 1224846-01-8 |
| MW: | 447.5 D |
ab 76,00 €
MK-3697
Artikelnummer: TGM-T1913-100mg
Description: MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). Target: OX Receptor. Smiles: COc1ccc(CNC(=O)c2cc(ncc2-c2nccs2)-c2cncc(C)c2)nc1OC. References: Anthony J. Roecker, et al. Bioorganic & Medicinal Chemistry Letters Available online 26...
| Anwendung: | Orexin receptor 2 antagonist |
| CAS | 1224846-01-8 |
| MW: | 447.51 D |
ab 45,00 €
MK-3697
Artikelnummer: Cay34718-10
MK-3697 is an orexin receptor 2 (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 3,600 nM). MK-3697 decreases active awake time and increases slow wave sleep (SWS) and rapid eye movement (REM) sleep in mice when administered at a dose of 100 mg/kg. It also decreases active awake time and...
| Schlagworte: | N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-[2,3'-bipyridine]-4-carboxamide |
| Anwendung: | Orexin receptor 2 antagonist |
| CAS | 1224846-01-8 |
| MW: | 447.5 D |
ab 100,00 €
