Zu "K04239" wurden 43 Artikel gefunden!
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TAK-994
Artikelnummer: Cay42336-1
An orexin receptor 2 agonist, selectively induces calcium mobilization in CHO-K1 cells expressing human OX2R over those expressing OX1R (EC50s = 0.019 and 14 µM, respectively), selective for OX2R over a panel of 106 enzymes, receptors, and ion channels at 10 µM, increases wakefulness time and wakefulness episode...
| Schlagworte: | Firazorexton,... |
| Anwendung: | Orexin receptor 2 (hypocretin receptor 2, HCRTR2) agonist |
| CAS | 2274802-95-6 |
| MW: | 470.51 D |
ab 605,00 €
JNJ-10397049
Artikelnummer: Cay14139-1
JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R). It has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors. Applied subcutaneously to rats, JNJ-10397049 decreases the latency to...
| Schlagworte: | N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea |
| Anwendung: | Orexin receptor type 2 (Ox2R) antagonist |
| CAS | 708275-58-5 |
| MW: | 484.2 D |
ab 76,00 €
MK-1064
Artikelnummer: TGM-T3722-1mg
Description: MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). Target: OX Receptor. Smiles: COc1ccc(CNC(=O)c2cc(cnc2-c2ccccn2)-c2cncc(Cl)c2)nc1OC. References: Roecker AJ et al. ChemMedChem. 2014 Feb,9(2):311-22.
| Schlagworte: | MK 1064, Urokinase inhibitor 1 |
| Anwendung: | Orexin OX2 receptor antagonist |
| CAS | 1207253-08-4 |
| MW: | 461.9 D |
ab 46,00 €
Anti-Orexin Receptor 2, N-terminal
Artikelnummer: ARG64347.100
Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Anti-Orexin Receptor 2
Artikelnummer: NSJ-R34646-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: OX2R, HCRTR2 Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, Orexin... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
836,00 €
Anti-Orexin Receptor 2
Artikelnummer: NSJ-R35910-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: OX2R, HCRTR2 Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, Orexin... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Almorexant (hydrochloride)
Artikelnummer: Cay13638-10
Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay). It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg....
| Schlagworte: | ACT 078573,... |
| Anwendung: | HCRTR1/2 antagonist |
| CAS | 913358-93-7 |
| MW: | 549 D |
ab 69,00 €
Anti-HCRTR2
Artikelnummer: E-AB-15812.120
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. Protein function:...
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, HCRTR2... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
TCS 1102
Artikelnummer: Cay18495-10
Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered...
| Schlagworte: | (2S)-N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide |
| Anwendung: | OX1R / OX2R antagonist |
| CAS | 916141-36-1 |
| MW: | 470.6 D |
ab 51,00 €
MK-1064
Artikelnummer: Cay20993-1
MK-1064 is an orexin 2 receptor (OX2R) antagonist that is selective for OX2R over OX1R (IC50s = 18 and 1,789 nM, respectively). It decreases the amount of time spent in active wake and increases the time spent in rapid eye movement (REM) sleep and slow-wave sleep (SMS) in mice, rats, dogs, and rhesus monkeys when...
| Schlagworte: | 5''-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-[2,2':5',3''-terpyridine]-3'-carboxamide |
| Anwendung: | Orexin OX2 receptor antagonist |
| CAS | 1207253-08-4 |
| MW: | 461.9 D |
ab 58,00 €
Orexin 2 Receptor Agonist
Artikelnummer: Cay22937-1
Orexin 2 receptor agonist is an agonist of the orexin 2 receptor (OX2R) with an EC50 value of 23 nM in a calcium influx assay. It is 70-fold selective for OX2R over OX1R (EC50 = 1,616 nM).Formal Name:...
| Schlagworte: | OX2R,... |
| Anwendung: | HCRTR2 inhibitor |
| CAS | 1796565-52-0 |
| MW: | 586.7 D |
ab 57,00 €
TCS-OX2-29
Artikelnummer: Cay17419-10
Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on...
| Schlagworte: | (2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone,... |
| Anwendung: | OX2R antagonist |
| CAS | 1610882-30-8 |
| MW: | 434 D |
ab 149,00 €