Zu "K04239" wurden 39 Artikel gefunden!
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MK-3697
Artikelnummer: LKT-M403007.1
MK-3697 is a selective orexin 2 receptor antagonist. SMILES: CC1=CC(=CN=C1)C2=NC=C(C(=C2)C(=O)NCC3=NC(=C(C=C3)OC)OC)C4=NC=CS4
| Schlagworte: | MK3697, M8238285OA, N-((5,6-dimethoxy-2-pyridinyl)methyl)-5'-methyl-5-(2-thiazolyl)-(2,3'-Bipyridine)-4-carboxamide,... |
| Anwendung: | Orexin 2 receptor antagonist |
| CAS | 1224846-01-8 |
| MW: | 447.5 D |
ab 76,00 €
Seltorexant
Artikelnummer: TGM-T12877L-100mg
Description: Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R). Target: OX Receptor. Smiles:...
| Schlagworte: | JNJ-42847922 |
| Anwendung: | Targets hypocretin (orexin) receptor 2 (HCRTR2) |
| CAS | 1293281-49-8 |
| MW: | 407.44 D |
ab 31,00 €
MK-1064
Artikelnummer: TGM-T3722-100mg
Description: MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). Target: OX Receptor. Smiles: COc1ccc(CNC(=O)c2cc(cnc2-c2ccccn2)-c2cncc(Cl)c2)nc1OC. References: Roecker AJ et al. ChemMedChem. 2014 Feb,9(2):311-22.
| Schlagworte: | MK 1064, Urokinase inhibitor 1 |
| Anwendung: | Orexin OX2 receptor antagonist |
| CAS | 1207253-08-4 |
| MW: | 461.9 D |
ab 48,00 €
TCS-OX2-29 HCl
Artikelnummer: TGM-T4965L-10mg
Description: TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation. Target: Others. Smiles: C([C@@H](NCC=1C=CN=CC1)C(C)(C)C)(=O)N2CC=3C(=CC(OC)=C(OC)C3)CC2.Cl
| Schlagworte: | TCS-OX229, TCS OX229, TCSOX 229, TCS OX2 29, TCSOX-229, TCSOX229 |
| Anwendung: | OX2R antagonist |
| CAS | 1610882-30-8 |
| MW: | 433.97 D |
ab 242,00 €
SB-649868
Artikelnummer: TGM-T5498-100mg
Description: SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). Target: OX Receptor. Smiles: Cc1nc(C(=O)N2CCCC[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccc(F)cc1. References: Faedo S, et al. Functional and binding kinetic studies...
| Schlagworte: | GSK649868 |
| Anwendung: | Orexin receptor (Ox-1-R, Ox-2-R) antagonist |
| CAS | 380899-24-1 |
| MW: | 477.55 D |
ab 31,00 €
MK-3697
Artikelnummer: TGM-T1913-100mg
Description: MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). Target: OX Receptor. Smiles: COc1ccc(CNC(=O)c2cc(ncc2-c2nccs2)-c2cncc(C)c2)nc1OC. References: Anthony J. Roecker, et al. Bioorganic & Medicinal Chemistry Letters Available online 26...
| Anwendung: | Orexin receptor 2 antagonist |
| CAS | 1224846-01-8 |
| MW: | 447.51 D |
ab 45,00 €
Orexin receptor type 2 (HCRTR2), partial, human, recombinant
Artikelnummer: CSB-YP010232HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-75aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG YIIVFVVALI GNVLV. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test....
| Schlagworte: | Ox2R, Ox2-R, Ox-2-R, HCRTR2, Orexin receptor type 2, Hypocretin receptor type 2, Recombinant Human Orexin receptor type 2... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 10.8 kD |
ab 347,00 €
Anti-HCRTR2
Artikelnummer: CSB-PA562577.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: HCRTR2. Antigen Species: Human
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, Hcr tr2... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-HCRTR2
Artikelnummer: CSB-PA949345.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: HCRTR2. Antigen Species: Human
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, Hcr tr2... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
JNJ-10397049
Artikelnummer: Cay14139-1
JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R). It has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors. Applied subcutaneously to rats, JNJ-10397049 decreases the latency to...
| Schlagworte: | N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea |
| Anwendung: | Orexin receptor type 2 (Ox2R) antagonist |
| CAS | 708275-58-5 |
| MW: | 484.2 D |
ab 67,00 €
Anti-Orexin Receptor 2, N-terminal
Artikelnummer: ARG64347.100
Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
822,00 €
Anti-Orexin Receptor 2
Artikelnummer: NSJ-R34646-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: OX2R, HCRTR2 Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]
| Schlagworte: | Anti-Ox2R, Anti-Ox2-R, Anti-HCRTR2, Anti-Ox-2-R, Anti-Orexin receptor type 2, Anti-Hypocretin receptor type 2, Orexin... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
790,00 €