K252c

K252c is a cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA, respectively). It induces apoptosis in human chronic myelogenous leukemia cancer cells. In human foreskin fibroblast cells, it reduces focus formation induced by human cytomegalovirus (HCMV) strains sensitive and resistant to Ganciclovir (Cay-13853) with IC50s of 0.32 and 0.17 µM for HCMV A6245 and HCMV-6, respectively. It also inhibits the non-kinase enzymes beta-lactamase, chymotrypsin, and malate dehydrogenase with IC50s of 8, 10, and 8 µM, suggesting less kinase-selectivity than was originally described.Formal Name: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one. CAS Number: 85753-43-1. Synonyms: SD 1825, Staurosporine aglycone. Molecular Formula: C20H13N3O. Formula Weight: 311.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 500 µg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: slightly soluble. lambdamax: 233, 290, 333, 359 nm. SMILES: O=C1NCC2=C1C(C3=CC=CC=C3N4)=C4C5=C2C6=C(C=CC=C6)N5. InChi Code: InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24). InChi Key: MEXUTNIFSHFQRG-UHFFFAOYSA-N.