Zu "K02677" wurden 123 Artikel gefunden!

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Calphostin C
Calphostin C

Artikelnummer: Cay15383-100

Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 µM for PKA) by competing at the binding site for diacylglycerol and phorbol esters. As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet...
Schlagworte: Cladochrome E, PKF 115-584, UCN 1028C,...
Anwendung: PKC inhibitor
CAS 121263-19-2
MW: 790.8 D
ab 123,00 €
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Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate

Artikelnummer: AG-CN2-0010-M001

Most commonly-used phorbol ester, Binds to and activates protein kinase C (PKC) at nM concentrations, Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors...
Schlagworte: PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate
Anwendung: PKC activator
CAS 16561-29-8
MW: 616,8 D
ab 28,00 €
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Staurosporine
Staurosporine

Artikelnummer: AG-CN2-0022-C100

Isolated from Streptomyces spiralis. Antibiotic. Antifungal and anti-yeast activity. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation. Potent, cell permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein...
Schlagworte: Antibiotic AM2282, Antibiotic 230, CCRIS 3272
Anwendung: Protein kinase inhibitor, Apoptosis inducer
CAS 62996-74-1
MW: 466,5 D
ab 50,00 €
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Staurosporine
Staurosporine

Artikelnummer: LKT-S7600.1

A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
Schlagworte: AM-2282, STS
Anwendung: PKC inhibitor
CAS 62996-74-1
MW: 466,5 D
ab 45,00 €
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Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate

Artikelnummer: Cay10008014-1

Phorbol 12-myristate 13-acetate (PMA) is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (alpha, betaI, betaII, gamma) and group B (delta, epsilon, eta, theta) isoforms. Phorbol esters, including PMA, are structurally analogous to diacylglycerol and...
Schlagworte: 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA,...
Anwendung: PKC activator
CAS 16561-29-8
MW: 616.8 D
ab 37,00 €
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Staurosporine
Staurosporine

Artikelnummer: Cay81590-1

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
Schlagworte: Stsp,...
Anwendung: PKC inhibitor
CAS 62996-74-1
MW: 466.5 D
ab 32,00 €
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Enzastaurin
Enzastaurin

Artikelnummer: Cay11601-5

Enzastaurin is a potent inhibitor of PKCbeta (IC50 = 6 nM), with modest selectivity over PKCalpha, PKCgamma, and PKCepsilon (IC50 = 39, 83, and 110 nM, respectively). At 3 µM, enzastaurin also inhibits signaling through the Akt pathway. It suppresses angiogenesis, induces apoptosis, and reduces proliferation of...
Schlagworte: LY317615, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Anwendung: PKCbeta inhibitor
CAS 170364-57-5
MW: 515.6 D
ab 87,00 €
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Gö 6976
Gö 6976

Artikelnummer: Cay13310-1

Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCalpha and PKCbeta1, respectively. It does not inhibit the activity of PKCdelta, PKCepsilon, or PKCzeta (IC50s > 3 µM), indicating a preference for the Ca2+-dependent subtypes, PKCalpha and...
Schlagworte: PD 406976, 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Anwendung: PKCalpha / PKCbeta1 inhibitor
CAS 136194-77-9
MW: 378.4 D
ab 49,00 €
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Bisindolylmaleimide IX (mesylate)
Bisindolylmaleimide IX (mesylate)

Artikelnummer: Cay13334-1

Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively). It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 µM) and calcium/calmodulin kinase II...
Schlagworte: BIM IX, Ro 31-8220, carbamimidothioic acid,...
Anwendung: PKC inhibitor
CAS 138489-18-6
MW: 553.7 D
ab 44,00 €
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Anti-phospho-PKCalpha/beta II(Thr638/641)
Anti-phospho-PKCalpha/beta II(Thr638/641)

Artikelnummer: E-AB-68108.120

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also...
Schlagworte: Anti-phospho-PKCA, Anti-phospho-PRKCA, Anti-phospho-PKC-A, Anti-phospho-PKC-alpha, EC=2.7.11.13, Anti-phospho-Protein...
Anwendung: IHC, IF
Reaktivität: Human, Mouse, Rat
ab 181,00 €
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Anti-phospho-PKC (pan) (betaII Ser660)
Anti-phospho-PKC (pan) (betaII Ser660)

Artikelnummer: E-AB-68164.120

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members...
Schlagworte: Anti-phospho-PKCA, Anti-phospho-PRKCA, Anti-phospho-PKC-A, Anti-phospho-PKC-alpha, EC=2.7.11.13, Anti-phospho-Protein...
Anwendung: WB
Reaktivität: Human, Mouse, Rat
ab 181,00 €
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Anti-phospho-PKCalpha(Ser319)
Anti-phospho-PKCalpha(Ser319)

Artikelnummer: E-AB-68183.120

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members...
Schlagworte: Anti-phospho-PKCA, Anti-phospho-PRKCA, Anti-phospho-PKC-A, Anti-phospho-PKC-alpha, EC=2.7.11.13, Anti-phospho-Protein...
Anwendung: WB
Reaktivität: Human, Mouse, Rat
ab 181,00 €
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