Zu "K02677" wurden 193 Artikel gefunden!
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Phorbol 12-myristate 13-acetate
Artikelnummer: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
| Schlagworte: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
| Anwendung: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.8 D |
ab 58,00 €
Phorbol 12-myristate 13-acetate
Artikelnummer: AG-CN2-0010-M001
Most commonly-used phorbol ester, Binds to and activates protein kinase C (PKC) at nM concentrations, Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors...
| Schlagworte: | PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate |
| Anwendung: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616,8 D |
ab 44,00 €
Staurosporine
Artikelnummer: LKT-S7600.1
A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
| Schlagworte: | AM-2282, STS |
| Anwendung: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
ab 64,00 €
Staurosporine
Artikelnummer: Cay81590-1
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
| Schlagworte: | Stsp,... |
| Anwendung: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466.5 D |
ab 53,00 €
Anti-Recombinant PKC alpha, clone 11A3
Artikelnummer: E-AN300721L.100
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members...
| Schlagworte: | Anti-PRKCA, Anti-Protein kinase C alpha type, Recombinant PKC alpha Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-phospho-PKC alpha (Thr497) / Protein kinase C alpha,...
Artikelnummer: NSJ-FY12403
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-PKC alpha Thr497 antibody recognizes protein kinase C alpha phosphorylated at threonine 497, an activation site essential for catalytic function. PKC alpha is a member of the conventional...
| Schlagworte: | Anti-phospho-PRKCA, Anti-phospho-Protein kinase C alpha type, Phospho-PKC alpha (Thr497) Antibody / Protein kinase C alpha |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Staurosporine
Artikelnummer: AG-CN2-0022-M001
Isolated from Streptomyces spiralis. Antibiotic. Antifungal and anti-yeast activity. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation. Potent, cell permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein...
| Schlagworte: | Antibiotic AM2282, Antibiotic 230, CCRIS 3272 |
| Anwendung: | Protein kinase inhibitor, Apoptosis inducer |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
ab 33,00 €
Anti-Phospho-PKCalpha (Thr638) Monoclonal Recombinant...
Artikelnummer: E-AN300149L.100
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members...
| Schlagworte: | PKCA, PRKCA, PKC-A, PKC-alpha, Protein kinase C alpha type, Recombinant Phospho-PKCalpha (Thr638) Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Calphostin C
Artikelnummer: Cay15383-100
Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 µM for PKA) by competing at the binding site for diacylglycerol and phorbol esters. As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet...
| Schlagworte: | Cladochrome E, PKF 115-584, UCN 1028C,... |
| Anwendung: | PKC inhibitor |
| CAS | 121263-19-2 |
| MW: | 790.8 D |
ab 212,00 €
Suramin, hexasodium salt
Artikelnummer: AG-CR1-3575-M050
Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1...
| Schlagworte: | Germanin, NSC 34936, SK 24728 |
| Anwendung: | ATPase Inhibitor |
| Wirt: | Synthetic |
| CAS | 129-46-4 |
| MW: | 1429,1 D |
ab 77,00 €
Enzastaurin
Artikelnummer: Cay11601-5
Enzastaurin is a potent inhibitor of PKCbeta (IC50 = 6 nM), with modest selectivity over PKCalpha, PKCgamma, and PKCepsilon (IC50 = 39, 83, and 110 nM, respectively). At 3 µM, enzastaurin also inhibits signaling through the Akt pathway. It suppresses angiogenesis, induces apoptosis, and reduces proliferation of...
| Schlagworte: | LY317615, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
| Anwendung: | PKCbeta inhibitor |
| CAS | 170364-57-5 |
| MW: | 515.6 D |
ab 128,00 €
Bisindolylmaleimide IX (mesylate)
Artikelnummer: Cay13334-1
Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively). It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 µM) and calcium/calmodulin kinase II...
| Schlagworte: | BIM IX, Ro 31-8220, carbamimidothioic acid,... |
| Anwendung: | PKC inhibitor |
| CAS | 138489-18-6 |
| MW: | 553.7 D |
ab 67,00 €