K-252c

Off-white to yellow crystalline solid. Soluble in DMSO or methanol. Insoluble in water. Indolocarbazole alkaloid antibiotic., Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A), Anticancer compound. Cytotoxic againt various cancer cell lines, Apoptosis inducer, Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV), LACTB (?-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor, Inhibits mixed lineage kinase (MLK).