GDC-0941

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110alpha, beta, delta, and gamma with IC50 values of 3, 33, 3, and 75 nM, respectively. It is much less effective against class II-IV isoforms of PI3K and against mTOR. GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.Formal Name: 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine. CAS Number: 957054-30-7. Synonyms: GNE-0941, Pictilisib, Pictrelisib. Molecular Formula: C23H27N7O3S2. Formula Weight: 513.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.15 mg/ml. lambdamax: 213, 260, 319 nm. SMILES: CS(N(CC1)CCN1CC(S2)=CC3=C2C(N4CCOCC4)=NC(C5=C(C=NN6)C6=CC=C5)=N3)(=O)=O. InChi Code: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27). InChi Key: LHNIIDJUOCFXAP-UHFFFAOYSA-N.