Zu "K00922" wurden 358 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
LY294002
Artikelnummer: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
| Schlagworte: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Anwendung: | PI3K inhibitor |
| CAS | 154447-36-6 |
| MW: | 307.3 D |
ab 42,00 €
PI-3 Kinase Lipid Substrate
Artikelnummer: BPS-40560
PI/PS (4:1, w/w) unilamellar vesicle, prepared with L-alpha-phosphatidylinositol (Liver, Bovine) (sodium salt) and L-alpha-phosphatidylserine (Brain, Porcine) (sodium salt). Lipid monolayer was formed by sonication. Application: Useful as a substrate for PI-3 kinase activity assays and other lipid kinases....
| Anwendung: | PI-3 kinase substrate |
581,00 €
Wortmannin
Artikelnummer: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
| Schlagworte: | KY 12420,... |
| Anwendung: | PI3K inhibitor |
| CAS | 19545-26-7 |
| MW: | 428.4 D |
ab 72,00 €
NEU
Zandelisib
Artikelnummer: Cay44440-1
Zandelisib is an inhibitor of PI3Kdelta (IC50 = 0. nM). Formal Name: 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[1,1-dimethyl-2-[2-(1-methyl-4-piperidinyl)phenyl]ethyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine. CAS Number: 1401436-95-0. Synonyms: ME-401 PWT143. Molecular Formula: C31H38F2N8O. Formula Weight:...
| Schlagworte: | ME-401, PWT143,... |
| Anwendung: | PI3Kdelta inhibitor |
| CAS | 1401436-95-0 |
| MW: | 576.7 D |
ab 34,00 €
NEU
Roginolisib
Artikelnummer: Cay44445-10
Roginolisib is an inhibitor of PI3Kdelta (IC50 = 0. µM). It is selective for PI3Kdelta over PI3Kalpha, PI3Kbeta, PI3Kgamma, VPS34, and PI3KC2beta (IC50s = 0. 1. 10. 5. and 5. µM, respectively). Roginolisib inhibits the growth of SU-DHL-6 B cell lymphoma cells that endogenously express PI3Kdelta (GI50 = 0. µM) but...
| Schlagworte: | IOA-244, MSC2360844,... |
| Anwendung: | PI3Kdelta inhibitor |
| CAS | 1305267-37-1 |
| MW: | 526.58 D |
ab 290,00 €
3-Methyladenine
Artikelnummer: Cay13242-25
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....
| Schlagworte: | 3-MA, NSC 66389, 3-methyl-3H-purin-6-amine |
| Anwendung: | PI3K inhibitor |
| CAS | 5142-23-4 |
| MW: | 149.2 D |
ab 50,00 €
Anti-Recombinant PI3-Kinase p110alpha, clone 7C1
Artikelnummer: E-AN301301L.100
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in...
| Schlagworte: | Anti-PIK3CA, Anti-Phosphoinositide 3-kinase alpha, Anti-Serine/threonine protein kinase PIK3CA,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
391,00 €
Anti-Recombinant PI3 Kinase p110 alpha, clone A333
Artikelnummer: E-AN301630L.100
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to...
| Schlagworte: | Anti-PIK3CA, Anti-Phosphoinositide 3-kinase alpha, Anti-Serine/threonine protein kinase PIK3CA,... |
| Anwendung: | WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Anti-PIK3CB / PI3 Kinase p110 beta, clone 30P53
Artikelnummer: NSJ-FY12367
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. PIK3CB antibody detects phosphatidylinositol 4,5 bisphosphate 3 kinase catalytic subunit beta, also known as PI3 kinase p110 beta. This protein is one of the catalytic isoforms of class I PI3 kinases,...
| Schlagworte: | Anti-PIK3CB, Anti-Serine/threonine protein kinase PIK3CB, Anti-Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa... |
| Anwendung: | WB, IHC, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-Zebrafish Pik3cb /...
Artikelnummer: NSJ-RZ1232
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration, intracellular signal transduction, and phosphatidylinositol-3-phosphate biosynthetic process....
| Schlagworte: | Anti-pik3cb, EC=2.7.1.153, Anti-phosphatidylinositol-4,5-bisphosphate 3-kinase, Zebrafish Pik3cb Antibody /... |
| Anwendung: | IHC (paraffin), IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | zebrafish |
948,00 €
Ifupinostat
Artikelnummer: Cay44447-1
Ifupinostat is a dual inhibitor of PI3Kalpha and histone deacetylase (HDAC). InChI: InChI=1S/C23H25N9O3S/c1-24-18-4-3-14(10-25-18)20-28-17-9-16(36-19(17)21(29-20)32-5-7-35-8-6-32)13-31(2)23-26-11-15(12-27-23)22(33)30-34/h3-4,9-12,34H,5-8,13H2,1-2H3,(H,24,25)(H,30,33) InChIKey: TWJZFXHSPBBPNI-UHFFFAOYSA-N SMILES:...
| Schlagworte: | BEBT-908, CUDC-908,... |
| Anwendung: | PI3Kalpha / HDAC dual inhibitor |
| CAS | 1235449-52-1 |
| MW: | 507,57 D |
ab 97,00 €
Tersolisib
Artikelnummer: Cay44458-1
Tersolisib is an allosteric inhibitor of kinase-domain mutant forms of PI3Kalpha. It inhibits PI3Kalpha containing mutations at the histidine in position 1047, including PI3KalphaH1047R, the methionine in position 1043, including PI3KalphaM1043I, and the glycine in position 1049, including PI3KalphaG1049R. It is...
| Schlagworte: | STX-478, N-(2-amino-5-pyrimidinyl)-N'-[(1R)-1-(5,7-difluoro-3-methyl-2-benzofuranyl)-2,2,2-trifluoroethyl]-urea |
| Anwendung: | Kinase-domain mutant forms PI3Kalpha allosteric inhibitor |
| CAS | 2883540-92-7 |
| MW: | 401,3 D |
ab 73,00 €