Dexrazoxane

Dexrazoxane is an iron chelator that exhibits cardioprotective, antioxidative, pro-angiogenic, and anti-parasitic activities. Dexrazoxane decreases superoxide formation and prevents anthracycline-induced cardiotoxicity. In animal models of myocardial infarction, dexrazoxane decreases infarct size, increases capillary density, and improves cardiac function. Additionally, this compound displays antimalarial benefit, inhibiting growth of Plasmodium.