Dexrazoxane

Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIalpha. Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 µM), and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.Formal Name: 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-2,6-piperazinedione. CAS Number: 24584-09-6. Synonyms: ICRF 187, NSC 169780. Molecular Formula: C11H16N4O4. Formula Weight: 268.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 0.25 mg/ml. SMILES: O=C(N1)CN(C[C@H](C)N2CC(NC(C2)=O)=O)CC1=O. InChi Code: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1. InChi Key: BMKDZUISNHGIBY-ZETCQYMHSA-N.