AZD 7507

AZD 7507 is an inhibitor of CSF-1 receptor tyrosine kinase (FMS, IC50 = 3 nM). It is selective for FMS over c-KIT, aurora kinase 5 (ARK-5), FMS-related tyrosine kinase 4 (FLT4), p90 ribosomal S6 kinase (RSK1), and 77 other kinases at 1 µM. AZD 7505 (100 nM) induces apoptosis in isolated Fms+ mouse bone marrow cells but not Fms- mouse bone marrow cells. In vivo, AZD 7505 (100 mg/kg per day) reduces the levels of tumor-associated Fms+ macrophages, increases the number of tumor-associated CD8+ T cells, decreases tumor weight, and increases survival in a UN-KPC-960 murine model of pancreatic ductal adenocarcinoma (PDAC). It decreases alpha-smooth muscle actin (alpha-Sma) levels and increases E-cadherin levels on isolated UN-KPC-960 tumor tissue, as well as reduces the levels of Ifn-gamma, Il-10, Il-17a, chemokine (C-X-C motif) ligand 2 (Cxcl2), chemokine (C-C motif) ligand 2 (Ccl2), Ccl7, and Ccl12 in protein lysates from the same tumors.Formal Name: 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide. CAS Number: 1041852-85-0. Molecular Formula: C23H27FN6O3. Formula Weight: 454.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 292, 365 nm. SMILES: O=C(C1=C(NC2=CC=C(C)C=C2F)C3=C(C=C(C(N4CCN(CC4)CCO)=C3)OC)N=N1)N. InChi Code: InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9-10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25,32)(H,26,27). InChi Key: CPDGCAFPSYOTGO-UHFFFAOYSA-N.