Zu "K05090" wurden 111 Artikel gefunden!

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GW 2580
GW 2580

Artikelnummer: Cay15411-25

cFMS kinase is the cellular homolog of the v-FMS oncogene product of the Susan McDonough strain of the feline sarcoma virus. It can autophosphorlyate colony-stimulating factor (CSF-1), which promotes the survival, proliferation, and differentiation of mononuclear phagocytes. GW 2580 selectively inhibits cFMS kinase...
Schlagworte: 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
Anwendung: CSF1R kinase inhibitor
CAS 870483-87-7
MW: 366.4 D
ab 37,00 €
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PLX5622
PLX5622

Artikelnummer: Cay28927-1

Schlagworte: 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine
Anwendung: CSF1R inhibitor
CAS 1303420-67-8
MW: 395.4 D
ab 57,00 €
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CSF1R, Fc-Fusion, Avi-Tag, Biotin-Labeled
CSF1R, Fc-Fusion, Avi-Tag, Biotin-Labeled

Artikelnummer: BPS-79343-1

Human colony stimulating factor 1 receptor (CSF1R), also known as FMS and CD115, GenBank Accession No. NM_005211, a.a. 20-512, with C-terminal Avi-Tag fused to the Fc portion of Human IgG1 and expressed in a HEK293 cell expression system. This protein is enzymatically biotinylated using AviTag(TM) technology. MW=83...
Schlagworte: FMS, CD115, CSF1R, CSF-1R, CSF-1-R, M-CSF-R, EC=2.7.10.1, CSF-1 receptor, Proto-oncogene c-Fms, Macrophage...
Anwendung: Immunotherapy
Reaktivität: Human
MW: 83 kD
ab 374,00 €
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FLT3-IN-2
FLT3-IN-2

Artikelnummer: Cay30070-25

FLT3-IN-2 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3), c-Kit, and c-FMS (IC50s = <1 µM for all).
Schlagworte: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine
Anwendung: FLT3 / c-Kit / c-FMS inhibitor
CAS 923562-23-6
MW: 416.8 D
ab 44,00 €
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AC-710
AC-710

Artikelnummer: Cay29498-10

AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...
Schlagworte: N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy...
Anwendung: PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor
CAS 1351522-04-7
MW: 562.7 D
ab 35,00 €
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BLZ-945
BLZ-945

Artikelnummer: Cay19626-1

BLZ-945 is a selective inhibitor of the colony stimulating factor 1 receptor (CSF1R) with an IC50 value of 1 nM. It is more than 1,000-fold selective against its closest receptor tyrosine kinase homologs. It has been shown to inhibit CSF1-dependent proliferation with an EC50 value of 67 nM in bone marrow-derived...
Schlagworte: 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide
Anwendung: Anticancer compound, CSF-1R / c-Fms inhibitor
CAS 953769-46-5
MW: 398.5 D
ab 112,00 €
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Pexidartinib
Pexidartinib

Artikelnummer: Cay18271-25

Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3...
Schlagworte: PLX3397, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Anwendung: KIT / CSF1R / FLT3 inhibitor
CAS 1029044-16-3
MW: 417.8 D
ab 62,00 €
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Ki20227
Ki20227

Artikelnummer: Cay22258-10

Ki20227 is an inhibitor of macrophage colony stimulating factor 1 (CSF1) receptor tyrosine kinase (c-Fms, IC50 = 2 nM). It inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells and reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM). Ki20227 suppresses development of...
Schlagworte: N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]-urea
Anwendung: CSF-1 receptor inhibitor
CAS 623142-96-1
MW: 480.5 D
ab 37,00 €
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BLZ-945
BLZ-945

Artikelnummer: SYN-1197-M001

Soluble in DMSO. BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC(50) of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRbeta ) as well as more than...
Schlagworte: BLZ945
Anwendung: CSF1R / c-FMS inhibitor
CAS 953769-46-5
MW: 398,5 D
ab 211,00 €
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CSF1R, untagged (FMS, CD115)
CSF1R, untagged (FMS, CD115)

Artikelnummer: BPS-79110

Human Colony stimulating factor 1 receptor (CSF1R), also known as FMS and CD115, GenBank Accession No. BC047521, a.a. 538-end with no tag, MW=50 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
Schlagworte: FMS, CSF1R, CD115, CSF-1R, M-CSF-R, CSF-1-R, EC=2.7.10.1, CSF-1 receptor, Proto-oncogene c-Fms, Macrophage...
Anwendung: Enzyme kinetics, Inhibitor screening, Selectivity profiling
Reaktivität: Human
449,00 €
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Human CSF1R - M-CSFR ELISA Kit
Human CSF1R - M-CSFR ELISA Kit

Artikelnummer: KOA0478

Natural and recombinant human CSF1R. There is no detectable cross-reactivity with other relevant proteins. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic...
Schlagworte: FMS, CD115, CSF1R, CSF-1R, M-CSF-R, CSF-1-R, EC=2.7.10.1, CSF-1 receptor, Proto-oncogene c-Fms, Macrophage...
Anwendung: ELISA
Reaktivität: Human
673,00 €
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Mouse CSF1R - M-CSFR ELISA Kit
Mouse CSF1R - M-CSFR ELISA Kit

Artikelnummer: KOA0479

Natural and recombinant mouse CSF1R. There is no detectable cross-reactivity with other relevant proteins. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic...
Schlagworte: Csfmr, CD115, Csf1r, CSF-1R, M-CSF-R, CSF-1-R, EC=2.7.10.1, CSF-1 receptor, Proto-oncogene c-Fms, Macrophage...
Anwendung: ELISA
Reaktivität: Mouse
673,00 €
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