Anti-RNA Polymerase II, Phospho (S5)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A304-408A-T 10 µl (2 µg) -

2 - 8 Werktage*

164,00 €
A304-408A 100 µl -

2 - 8 Werktage*

626,00 €
 
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using... mehr
Produktinformationen "Anti-RNA Polymerase II, Phospho (S5)"
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA- dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome. [The UniProt Consortium]
Schlagworte: Anti-POLR2, Anti-POLR2A, EC=2.7.7.6, EC=2.7.7.48, Anti-RNA polymerase II subunit B1, Anti-DNA-directed RNA polymerase II subunit A, Anti-DNA-directed RNA polymerase II subunit RPB1, Anti-RNA-directed RNA polymerase II subunit RPB1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A304-408A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse (Erwartet: D. melanogaster)
Immunogen: synthetic peptide. The epitope recognized by A304-408A-T maps to a region between residue Immunogen for A304-408A was a phosphorylated synthetic peptide, which represented a portion of human RNA Polymerase II (GeneID 5430) around serine 5 of the C-terminal repeat YSPTSPS. of human RNA Polymerase II using the numbering given in entry NP_000928.1 (GeneID 5430).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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