Anti-phospho-PAK4 (Ser474) + PAK5 (Ser602) + PAK6 (Ser560)

Anti-phospho-PAK4 (Ser474) + PAK5 (Ser602) + PAK6 (Ser560)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG43177.100 100 µl - -

6 - 14 Werktage*

658,00 €
 
Protein function: Serine/threonine protein kinase that plays a role in a variety of different... mehr
Produktinformationen "Anti-phospho-PAK4 (Ser474) + PAK5 (Ser602) + PAK6 (Ser560)"
Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell- cycle regulatory protein CDKN1A and by phosphorylating RAN. {ECO:0000269, PubMed:11278822, ECO:0000269, PubMed:11313478, ECO:0000269, PubMed:14560027, ECO:0000269, PubMed:15660133, ECO:0000269, PubMed:20507994, ECO:0000269, PubMed:20631255, ECO:0000269, PubMed:20805321, ECO:0000269, PubMed:26607847}. [The UniProt Consortium]
Schlagworte: Anti-phospho-PAK4, Anti-phospho-PAK-4, Anti-phospho-PAK-4, Anti-phospho-KIAA1142, Anti-phospho-p21-activated kinase 4, Anti-phospho-p21-activated kinase 4, Anti-phospho-Serine/threonine-protein kinase PAK 4, Anti-phospho-Serine/threonine-protein kinase PA
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG43177

Eigenschaften

Anwendung: FC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Synthetic peptide derived from Human PAK4 phospho (Ser474) + PAK5 phospho (Ser602) + PAK6 phospho (Ser560)
MW: 64 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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