Anti-phospho-MYC (Thr58) (Myc Proto-oncogene Protein, c-Myc, Proto-oncogene c-Myc, Transcription Fac

MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Applications: Suitable for use in ELISA, Western Blot, and Dot Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:50-1:200, Dot Blot: 1:100-1:500, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.