Anti-phospho-beta Catenin (Tyr333)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG51844.50 50 µl - -

6 - 14 Werktage*

436,00 €
ARG51844.100 100 µl - -

6 - 14 Werktage*

624,00 €
 
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence... mehr
Produktinformationen "Anti-phospho-beta Catenin (Tyr333)"
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. [The UniProt Consortium]
Schlagworte: Anti-phospho-CTNNB, Anti-phospho-CTNNB1, Anti-phospho-Beta-catenin, Anti-phospho-Catenin beta-1
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG51844

Eigenschaften

Anwendung: WB, IHC (paraffin)
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Peptide sequence around phosphorylation site of tyrosine 333 (Y-T-Y(p)-E-K) derived from Human beta-catenin
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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