Anti-Gap-43 (Phospho-Ser41)

Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that Gap-43 serves to amplify path finding signals from the growth cone. Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP.Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser41 of Gap-43. Formulation: (Request formulation change), Peptide affinity-purified antibody. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.