Anti-ZAK (MLKLAK)

Anti-ZAK (MLKLAK)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F51004-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F51004-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. ZAK/MLKLAK is a member of the MAPKKK family of signal... mehr
Produktinformationen "Anti-ZAK (MLKLAK)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. ZAK/MLKLAK is a member of the MAPKKK family of signal transduction molecules. It possesses an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Protein function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. [The UniProt Consortium]
Schlagworte: Anti-ZAK, Anti-MRK, Anti-MLTK, Anti-HCCS4, Anti-HCCS-4, EC=2.7.11.25, Anti-MLK-related kinase, Anti-Mixed lineage kinase-related kinase, Anti-Human cervical cancer suppressor gene 4 protein, Anti-MLK-like mitogen-activated protein triple kinase, ZAK Antib
Hersteller: NSJ Bioreagents
Hersteller-Nr: F51004

Eigenschaften

Anwendung: WB, IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 271-300 from the human protein was used as the immunogen for this ZAK antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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