Anti-WNK1

Anti-WNK1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-514A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A301-514A-M 100 µl (10 blots) -

3 - 9 Werktage

299,00 €
A301-514A 100 µl (20 µg) -

3 - 9 Werktage

443,00 €
 
Protein function: Serine/threonine kinase which plays an important role in the regulation of... mehr
Produktinformationen "Anti-WNK1"
Protein function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. [The UniProt Consortium]
Schlagworte: Anti-p65, Anti-hWNK1, Anti-Kinase deficient protein, Anti-Erythrocyte 65 kDa protein, Anti-Protein kinase with no lysine 1, Anti-Protein kinase lysine-deficient 1, Anti-Serine/threonine-protein kinase WNK1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-514A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-514A-T maps to a region between residue 1625 and 1675 of human WNK lysine deficient protein kinase 1 using the numbering given in entry NP_061852.2 (GeneID 65125).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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