Anti-ULK1 (Phospho-Ser757) Rabbit (Clone RM48

Unc-51-like autophagy activating kinase 1 (ULK1), also known as autophagy-related 1 homolog (ATG1), is a kinase involved in initiating autophagy. It is composed of an N-terminal kinase domain, a proline serine-rich domain, and two C-terminal microtubule-interacting and transporter (MIT) domains. ULK1 forms a complex with ATG12, ATG5, and ATG15L1 to sequester cargo in autophagosomes prior to transport to and fusion with lysosomes. It is activated when AMP-activated protein kinase (AMPK) phosphorylates Ser317 and Ser777 in response to low nutrient availability and deactivated when mTORC1 phosphorylates Ser757. ULK1 phosphorylates and deactivates STING in response to STING-induced increases in levels of cyclic dinucleotides. Cayman's ULK1 (Phospho-Ser757) Rabbit Monoclonal Antibody (Clone RM488) can be used for Western blot (WB).. Cross reactivity: (+) ULK1 (phospho-Ser757): (-) Unmodified ULK1. (+) Human: (+) Mouse, (+) Rat.. Protein function: Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). [The UniProt Consortium]