Anti-Trpm2

Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 100%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 94%, Pig - 78%, Cynomolgus monkey - 83%. IHC Verification: succeed. WB Verification: Fail (K-562). IP Verification: -. IF Verification: -. FC Verification: -. IP-MS Verification: -. Cross reactivity: Not tested. Sandwich ELISA Verification: -. Antigen ID: ABS-P10089PAGND. Core Sequence: SEQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRFLCSF SSEKQENLSS WIPENIKKKE CVYFVESSKL SDAGKVVCAC GYTHEQHLEV AIKPHTFQGK EWDPKKHVQE MPTDAFGDIV FTDLSQKVGK YVRVSQDTPS SVIYQLMTQH WGLDVPNLLI SVTGGAKNFN MKLRLKSIFR RGLVKVAQTT GAWIITGGSH TGVMKQVGEA. Recombinant Antibody: Protein Function: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11804595, PubMed:19454650, PubMed:21753080, PubMed:22493272). Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress. The precise physiological activators are under debate, the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (By similarity). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change, the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular Ca(2+) passes through the channel and increases channel activity (By similarity). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:21753080). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (PubMed:21753080). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (By similarity). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis (PubMed:27533035, PubMed:27562954). Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (PubMed:20921208, PubMed:25817999). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection (PubMed:21709234). Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (PubMed:21753080). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca(2+) and Zn(2+) levels (By similarity). Confers susceptibility to cell death following oxidative stress (PubMed:25562606) [The Uniprot Consortium]