Anti-Topoisomerase IIalpha, clone YN01636m

Topo II is an endonuclease and a target molecule of some tumor drugs. At the same time, it is related to signal transduction, cell proliferation and apoptosis. The higher the expression level of Topo II, the higher the sensitivity to tumor drugs. At present, it is mostly used in the study of drug resistance of tumor. Protein function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation. [The UniProt Consortium]