Anti-Synaptophysin (C-Term) Rabbit Monoclonal Antibody (Clone RM258)

Synaptophysin is a transmembrane glycoprotein found in synaptic vesicle membranes of the CNS, neuroendocrine tissues, and certain tumors. It is comprised of a cytoplasmic N-terminus, four transmembrane domains with the two intravesicular loops containing one disulfide bond per loop, and a cytoplasmic C-terminus containing ten pentapeptide repeat domains. Nine of the repeat domains begin with a tyrosine residue subject to phosphorylation. Synaptophysin interacts with the v-SNARE synaptobrevin and the GTPase dynamin to facilitate exo-endocytosis coupling in the release of neurotransmitters. Mutations in SYP, the gene encoding synaptophysin, are associated with X-linked intellectual disability. Synaptophysin has commonly been used as a marker of synapses and synapse vesicles in the brain. Cayman's Synaptophysin (C-Term) Rabbit Monoclonal Antibody (Clone RM258) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes synaptophysin at approximately 38 kDa from human samples.Synonyms: SYP, Major Synaptic Vesicle Protein p38. Immunogen: Peptide from the C-terminal region of synaptophysin. Clone Designation: RM258. MW: 38 kDa. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Synaptophysin.