Anti-STING (Clone 2C8)

Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers. Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). Loss of STING regulation contributes to autoimmune disorders through increased IFN activity. The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection. Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA, Cay-14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING. Cayman's STING Monoclonal Antibody (Clone 2C8) can be used for ELISA, immunohistochemistry, and Western blot applications. The antibody recognizes STING at 42 kDa from human samples.Synonyms: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, MITA, MPYS, Stimulator of Interferon Genes, TMEM173, Transmembrane Protein 173. Immunogen: Human recombinant STING protein AA 139-379. Clone Designation: 2C8. Formulation: (Request formulation change), 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, IHC, and WB. UniProt Accession #: Q86WV6.