Anti-Siglec11

Anti-Siglec11 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Siglec11 from other sources has not been determined. Protein function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. [The UniProt Consortium]