Anti-Recombinant Caspase-2, clone C112698

Protein function: Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321) Acts as a positive regulator of apoptosis Acts as a negative regulator of apoptosis May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death [The UniProt Consortium]