Anti-Rabphilin 3A

Protein function: Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:8617225, PubMed:16203731). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993). Plays also a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474). [The UniProt Consortium]