Anti-PSMD14

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA002114.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA002114.100 100 µl -

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363,00 €
 
Protein function: Component of the 26S proteasome, a multiprotein complex involved in the... mehr
Produktinformationen "Anti-PSMD14"
Protein function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%
Schlagworte: Anti-POH1, Anti-PSMD14, EC=3.4.19.-, Anti-26S proteasome regulatory subunit RPN11, Anti-26S proteasome-associated PAD1 homolog 1, Anti-26S proteasome non-ATPase regulatory subunit 14
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA002114

Eigenschaften

Anwendung: ICC, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: AVDTAEQVYI SSLALLKMLK HGRAGVPMEV MGLMLGEFVD DYTVRVIDVF AMPQSGTGVS VEAVDPVFQA KMLDMLKQTG RPEMVVGWYH SHPGFGCWLS GVDINTQQSF EALSERAVAV VVDPIQSVKG KVVIDA (ATA-APrEST86205)

Datenbank Information

KEGG ID : K03030 | Passende Produkte
UniProt ID : O00487 | Passende Produkte
Gene ID : GeneID 10213 | Passende Produkte
Protein Atlas Nr. : ENSG00000115233

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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