Anti-PPM1D [30] Monoclonal Antibody -Knockout Validated

[KO] PPM1D Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity) [The Uniprot Consortium]