Zu "K10147" wurden 30 Artikel gefunden!
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Anti-PPM1D / Protein phosphatase 1D
Artikelnummer: NSJ-FY13402
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PPM1D antibody targets Protein phosphatase 1D (PPM1D), also known as Wip1, a serine-threonine phosphatase that functions as a key negative regulator of cellular stress response signaling. PPM1D belongs to the PP2C family of metal-dependent...
| Schlagworte: | Anti-PPM1D, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1, Anti-Protein phosphatase 2C isoform... |
| Anwendung: | WB, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
GSK2830371
Artikelnummer: Cay16973-5
The wild-type p53-induced phosphatase Wip1, also known as protein phosphatase magnesium-dependent 1 delta (PPM1D) or PP2Cdelta, modulates cell cycling and may contribute to some forms of cancer. GSK2830371 is a potent inhibitor of Wip1 (IC50 = 6 nM). It displays selectivity for Wip1 over 21 other phosphatases....
| Schlagworte: | 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophen... |
| Anwendung: | PPM1D / WIP1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461 D |
ab 51,00 €
CCT007093
Artikelnummer: Cay19992-1
CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including...
| Schlagworte: | 2E,5E-bis(2-thienylmethylene)-cyclopentanone |
| Anwendung: | PPM1D inhibitor |
| CAS | 176957-55-4 |
| MW: | 272.4 D |
ab 51,00 €
Anti-PPM1D
Artikelnummer: 600-401-DS3
Anti-PPM1D antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. PPM1D antibody is human, mouse and rat reactive. At least two isoforms of PPM1D are known to exist, this antibody will only detect the larger isoform. Protein function: Required for the relief of p53-dependent...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
GSK-2830371
Artikelnummer: LKT-G7240.1
Wip1 inhibitor.
| Anwendung: | Wip1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461.02 D |
ab 94,00 €
Anti-PPM1D
Artikelnummer: ARG54879.100
Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-PPM1D
Artikelnummer: E-AB-52172.120
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-PPM1D
Artikelnummer: ATA-HPA022277.100
Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
CCT007093
Artikelnummer: TGM-T1927-100mg
Description: CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 µM). Target: Apoptosis, Phosphatase, Autophagy. Smiles: O=C1\C(CC\C1=C/c1cccs1)=C\c1cccs1. References: Rayter S, et al. Oncogene. 2008, 27(8), 1036-1044.
| Anwendung: | PPM1D inhibitor |
| CAS | 176957-55-4 |
| MW: | 272.39 D |
ab 38,00 €
GSK 2830371
Artikelnummer: TGM-T6521-100mg
Description: GSK 2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. Target: Phosphatase. Smiles: Cc1ncc(Cl)cc1NCc1ccc(s1)C(=O)N[C@@H](CC1CCCC1)C(=O)NC1CC1. References: Gilmartin AG, et al. Nat Chem Biol. 2014, 10(3), 181-187
| Schlagworte: | GSK2830371 |
| Anwendung: | PPM1D / WIP1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461.02 D |
ab 46,00 €
PhosphoSens-Kinetic Phosphatase Activity Kit, - AQT0525
Artikelnummer: AQT-CSPS-AQT0525-K-1000
PhosphoSens Sensor Peptide Substrate AQT0525 is recommended for PPM1D (WIP1, PP2C-delta) PhosphoSens-Kinetic assays
| Schlagworte: | for PPM1D (WIP1, PP2C-delta) PhosphoSens-Kinetic assays |
| Anwendung: | Full activity progress curve generation in every well, IC50/Ki/kobs/TDI/mechanistic characterization |
| Spezies-Reaktivität: | human |
ab 721,00 €
PhosphoSens Phosphatase Substrate - AQT0525
Artikelnummer: AQT-CSPS-AQT0525-B-01
PhosphoSens Sensor Peptide Substrate AQT0525 is recommended for PPM1D (WIP1, PP2C-delta) PhosphoSens-Kinetic assays
| Schlagworte: | for PPM1D (WIP1, PP2C-delta) PhosphoSens-Kinetic assays |
| Anwendung: | PhosphoSens-Kinetic assays |
| Ursprungsart: | human |
ab 4.093,00 €