Zu "K10147" wurden 28 Artikel gefunden!
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GSK2830371
Artikelnummer: Cay16973-5
The wild-type p53-induced phosphatase Wip1, also known as protein phosphatase magnesium-dependent 1 delta (PPM1D) or PP2Cdelta, modulates cell cycling and may contribute to some forms of cancer. GSK2830371 is a potent inhibitor of Wip1 (IC50 = 6 nM). It displays selectivity for Wip1 over 21 other phosphatases....
| Schlagworte: | 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophen... |
| Anwendung: | PPM1D / WIP1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461 D |
ab 49,00 €
CCT007093
Artikelnummer: Cay19992-1
CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including...
| Schlagworte: | 2E,5E-bis(2-thienylmethylene)-cyclopentanone |
| Anwendung: | PPM1D inhibitor |
| CAS | 176957-55-4 |
| MW: | 272.4 D |
ab 49,00 €
Anti-PPM1D
Artikelnummer: 600-401-DS3
Anti-PPM1D antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. PPM1D antibody is human, mouse and rat reactive. At least two isoforms of PPM1D are known to exist, this antibody will only detect the larger isoform. Protein function: Required for the relief of p53-dependent...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
GSK-2830371
Artikelnummer: LKT-G7240.1
Wip1 inhibitor.
| Anwendung: | Wip1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461.02 D |
ab 94,00 €
Anti-PPM1D
Artikelnummer: ARG54879.100
Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-PPM1D
Artikelnummer: E-AB-52172.120
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-PPM1D
Artikelnummer: ATA-HPA022277.100
Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins...
| Schlagworte: | Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1,... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
CCT007093
Artikelnummer: TGM-T1927-100mg
Description: CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 µM). Target: Apoptosis, Phosphatase, Autophagy. Smiles: O=C1\C(CC\C1=C/c1cccs1)=C\c1cccs1. References: Rayter S, et al. Oncogene. 2008, 27(8), 1036-1044.
| Anwendung: | PPM1D inhibitor |
| CAS | 176957-55-4 |
| MW: | 272.39 D |
ab 38,00 €
GSK 2830371
Artikelnummer: TGM-T6521-100mg
Description: GSK 2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. Target: Phosphatase. Smiles: Cc1ncc(Cl)cc1NCc1ccc(s1)C(=O)N[C@@H](CC1CCCC1)C(=O)NC1CC1. References: Gilmartin AG, et al. Nat Chem Biol. 2014, 10(3), 181-187
| Schlagworte: | GSK2830371 |
| Anwendung: | PPM1D / WIP1 inhibitor |
| CAS | 1404456-53-6 |
| MW: | 461.02 D |
ab 46,00 €
NEU
![Anti-PPM1D [30] Monoclonal Antibody -Knockout Validated](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "Anti-PPM1D [30] Monoclonal Antibody -Knockout Validated")
Anti-PPM1D [30] Monoclonal Antibody -Knockout Validated
Artikelnummer: G-AGMB06758.100
[KO] PPM1D Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53...
| Schlagworte: | Anti-PPM1D, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1, Anti-Protein phosphatase 2C isoform... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 378,00 €
PPM1D (human), recombinant protein
Artikelnummer: ABS-PP-4624-L.100
Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins...
| Schlagworte: | Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta,... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 41.5 kD |
ab 115,00 €
PPM1D, Human protein phosphatase 1D magnesium-dependent,...
Artikelnummer: VHPS-7144
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | WIP1, PPM1D, PP2C-delta, EC=3.1.3.16, Protein phosphatase 1D, p53-induced protein phosphatase 1, Protein phosphatase 2C... |
| Anwendung: | RNA quantification |
45,00 €