Anti-PD-1 Antibody (Sintilimab)

Sintilimab, also known as IBI308, is an humanized IgG4 monoclonal antibody targeting PD-1 ( Programmed cell death protein 1). It blocks the interaction of PD-1 with its ligands. The binding of Programmed Cell Death Protein 1 (PD-1), also known as CD279, a receptor expressed on activated T cells, to its ligands PD-L1 and PD-L2, negatively regulates immune responses. Interferon expression (particularly IFN-gamma) from activated T cells induces expression of PD-L1 on tumor cells, which serves as a mechanism of adaptive immune resistance in many cancers. The PD-1 ligands are found on most cancer cells, and the PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for autoimmune diseases such as multiple sclerosis (MS), psoriatic arthritis, lupus, and type I diabetes. The PD-1/PDL-1 pathway is targeted by immune checkpoint inhibitors approved for the treatment of cancer, such as Pembrolizumab (Keytruda(R)) and Nivolumab (Opdivo(R)), both of which are used for many types of cancer and were considered blockbuster drugs. Other anti-PD-1 antibodies approved for cancer treatment include Cemiplimab, Dostarlimab, Retifanlimab, Toripalimab, and Tislelizumab. PD-L1-directed checkpoint inhibitors approved for cancer treatment include Atezolizumab, Durvalumab, Avelumab, and Cosibelimab. Sintilimab, sold under the name Tyvyt, is a monoclonal antibody that targets PD-1 and has been approved in China for the treatment of Hodgkins's disease.