Anti-PARP1

In 1X PBS, pH 7.4, with 0.09% sodium azide. PARP is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.Additional PARP1 pathway and chromatin-associated DNA repair studies may benefit from our PARP1 antibody page featuring recombinant rabbit monoclonal clone CFD-16 with knockdown-validated target recognition.