Anti-PAD3

Anti-PAD3
Anti-PAD3
   
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay33913-50 50 µl - -

6 - 10 Werktage*

137,00 €
Cay33913-100 100 µl - -

6 - 10 Werktage*

232,00 €
Cay33913-200 200 µl - -

6 - 10 Werktage*

342,00 €
 
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline... mehr
Produktinformationen "Anti-PAD3"
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, which include S100A3, trichohyalin, and filaggrin, resulting in the loss of a positive charge, which can alter protein structure and/or function. It exists as a homodimer and is composed of a C-terminal catalytic domain and an N-terminal domain that contains two immunoglobulin G (IgG) subdomains. PAD3 is primarily expressed by differentiated keratinocytes in the epidermis and hair follicles where it has roles in the shaping and mechanical strengthening of hair. It is also expressed by neural stem cells where it modulates cell death by regulating the nuclear translocation of apoptosis-inducing factor (AIF), in mammary glands where it citrullinates proteins during lactation, and cancer cells where it promotes cancer cell invasion. Mutations in PADI3 are associated with uncombable hair syndrome. Cayman's PAD3 Polyclonal Antibody can be used for immunohistochemistry (IHC). The antibody recognizes PAD3 from human samples.Synonyms: PADI3, PDI3, Peptidylarginine Deiminase 3, Protein Arginine Deiminase 3. Immunogen: Human PAD3 fragment expressed in E. coli. Clone Designation: Polyclonal. Formulation: This vial contains 50, 100, or 200 µl of protein A-purified polyclonal antibody. Storage Buffer: PBS, pH 7.0, with 0.03% ProClinTM 300. Host: Rabbit. Isotype: IgG. Applications: IHC. Cross Reactivity: (+) PAD3.
Schlagworte: Anti-PAD3, Anti-PADI3, Anti-Peptidylarginine deiminase III, Anti-Protein-arginine deiminase type-3, Anti-Protein-arginine deiminase type III
Hersteller: Cayman Chemical
Hersteller-Nr: 33913

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Human PAD3 fragment expressed in E. coli
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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