Zu "K01481" wurden 132 Artikel gefunden!
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PAD2 (human, recombinant)
Artikelnummer: Cay10785-50
Peptidyl arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is composed of an alpha/beta propeller domain, an IgG1 domain that contains calcium...
| Schlagworte: | PADI2, PAD-H19, PAD-H19, KIAA0994, Peptidylarginine deiminase II, Peptidylarginine deiminase II, Protein-arginine... |
| Anwendung: | Enzyme activity |
| Exprimiert in: | Insect cells |
ab 276,00 €
NEU
Anti-PAD2 (Clone 11C10)
Artikelnummer: Cay19820-100
Peptidyl arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is composed of an alpha/beta propeller domain, an IgG1 domain that contains calcium...
| Schlagworte: | PAD-H19, PADI2, Peptidylarginine Deiminase 2, Protein-Arginine Deiminase 2 |
| Anwendung: | ELISA, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
611,00 €
NEU
Anti-Recombinant PADI2, clone C112452
Artikelnummer: E-AN302832L.100
Protein function: Catalyzes the deimination of arginine residues of proteins [The UniProt Consortium]
| Schlagworte: | Anti-PADI2, Anti-PAD-H19, Anti-Peptidylarginine deiminase II, Anti-Protein-arginine deiminase type-2,... |
| Anwendung: | WB, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
Cl-Amidine (hydrochloride)
Artikelnummer: Cay10599-1
Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs, IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively). It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 µM, respectively). Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil...
| Schlagworte: | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride |
| Anwendung: | Peptidyl arginine deiminase (PAD) inhibitor |
| CAS | 1373232-26-8 |
| MW: | 347.2 D |
ab 76,00 €
PADI2 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-04320-100ug
Description: PADI2 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells with C-10xHis. The accession number is Q08642.
| Schlagworte: | Peptidylarginine deiminase II , Protein-arginine deiminase type-2 , Protein-arginine deiminase type II , Padi2 , Pdi2 ,... |
| MW: | 77.6 kD |
ab 125,00 €
GSK484 (hydrochloride)
Artikelnummer: Cay17488-5
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human...
| Schlagworte: | [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]... |
| Anwendung: | Reversible PAD4 inhibitor |
| CAS | 1652591-81-5 |
| MW: | 510 D |
ab 59,00 €
Citrulline-specific Probe-rhodamine
Artikelnummer: Cay16172-250
Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly...
| Schlagworte: | Rh-PG, Rhodamine Phenylglyoxal,... |
| Anwendung: | Fluorescent citrullination detection |
| CAS | 2309313-01-5 |
| MW: | 731.8 D |
ab 273,00 €
GSK 199 (hydrochloride)
Artikelnummer: Cay17489-5
GSK 199 is an inhibitor of peptidyl arginine deiminase 4 (PAD4, IC50 = 200 nM in the absence of calcium). It selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays. GSK 199 (10 µM) prevents histone H3 citrullination and neutrophil extracellular trap (NET) formation...
| Schlagworte: | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,... |
| Anwendung: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 469 D |
ab 116,00 €
GSK106 (hydrochloride)
Artikelnummer: Cay17490-5
Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 (Cay-17488)...
| Schlagworte: | (3-amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone, monohydrochloride |
| Anwendung: | Inactive PADI4 inhibitor control |
| CAS | 1652591-82-6 |
| MW: | 438 D |
ab 58,00 €
PAD3 (human, recombinant)
Artikelnummer: Cay10786-100
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, which include S100A3, trichohyalin, and filaggrin, resulting in the loss of a positive charge, which can alter protein structure and/or function. It exists as a homodimer and is...
| Schlagworte: | PAD3, PADI3, Peptidylarginine deiminase III, Peptidylarginine deiminase III, Protein-arginine deiminase type-3,... |
| Anwendung: | Enzyme activity |
734,00 €
PAD1 (human, recombinant)
Artikelnummer: Cay10784-100
Peptidyl arginine deiminase 1 (PAD1) is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It exists as a monomer and is composed of a...
| Schlagworte: | PAD1, PADI1, Peptidylarginine deiminase I, Peptidylarginine deiminase I, Protein-arginine deiminase type-1,... |
| Anwendung: | Enzyme kinetics |
| MW: | 76,4 kD |
734,00 €
Anti-PAD6 (Clone 4B7)
Artikelnummer: Cay25965-100
Protein arginine deiminase 6 (PAD6) is a homodimeric guanidine-modifying enzyme belonging to the amidinotransferase superfamily. It is a calcium-dependent enzyme that catalyzes the post-translational modification of target proteins by converting arginine to citrulline. PAD6 is expressed in mammalian oocytes, sperm...
| Schlagworte: | Anti-PAD6, Anti-PADI6, Anti-hPADVI, Anti-hPADVI, Anti-Peptidylarginine deiminase VI, Anti-Peptidylarginine deiminase VI,... |
| Anwendung: | ELISA, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
611,00 €