Anti-Neural cell adhesion molecule L1 (L1CAM, L1 cell adhesion molecule, CAML1, CD171, HSAS, HSAS1,

The neural cell adhesion molecule L1 (NCAM-L1/CD171), also called L1-CAM or L1, is an immunoglobulin superfamily (IgSF) adhesion molecule that is critical for neural development. NCAM-L1 binds homophilically and heterophilically with adhesion molecules including axonin-1, CD9, neurocan and integrins. Mutations of the gene encoding NCAM-L1 are associated with a subset of X-linked mental retardation syndromes, schizophrenia, and other neurological disorders. Cancer cells can proteolytically cleave NCAM-L1, releasing the soluble ectodomain. The mouse NCAM-L1 extracellular domain, aa19-1123, shares 87% and 98% aa identity with human and rat NCAM-L1, respectively. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 25ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.