Anti-NEU3 Antibody Pair

Capture antibody: Rabbit IgG in 50% Glycerol, 0.01M PBS, PH 7.4. Detection antibody: Rabbit IgG in 50% Glycerol, 0.01M PBS, PH 7.4. Application note: We recommend using the capture antibody at a concentration of 0.1ug/ml and the detection antibody at a concentration of 0.125ug/ml.Optimal dilutions should be determined experimentally by the researcher.. Protein function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)- sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin- mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452). [The UniProt Consortium]