Anti-N-cadherin

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin),also known as CDH2 (cadherin 2),is a classical member of the cadherin superfamily which also include E-,P-,R-,and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons,endothelial cells and cardiac myocytes . N-cadherin has functions in early brain morphogenesis,synaptogenesis and synaptic plasticity . Protein function: Calcium-dependent cell adhesion protein, preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [The UniProt Consortium]