Anti-LRRK2

In 1X PBS, pH 7.4, with 0.09% sodium azide. LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. It belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains. Protein function: Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. [The UniProt Consortium]