Zu "K08844" wurden 103 Artikel gefunden!
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CID-25014542
Artikelnummer: Cay29837-10
A LRRK2 inhibitor (IC50 = 15 nM), selective for LRRK2 over a panel of 44 other kinases but does inhibit MAPK4 and Pim-2 at 1 µM, inhibits FLT3 at 10 µM, decreases the production of Abeta42 in a reporter assay using H4 cells overexpressing Abeta42 (IC50 = 15 µM), inhibits EGF-induced activation of MAPK in...
| Schlagworte: | 5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Anwendung: | LRRK2 inhibitor |
| CAS | 220904-99-4 |
| MW: | 429.49 D |
ab 97,00 €
PF-06447475
Artikelnummer: Cay18375-10
PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 3 nM), an enzyme genetically linked to Parkinson's disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death. PF-06447475 has been shown to attenuate alpha-synuclein-induced dopaminergic...
| Schlagworte: | 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1527473-33-1 |
| MW: | 305.3 D |
ab 53,00 €
PF-06454589
Artikelnummer: Cay42957-10
PF-06454589 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 12 nM for the wild-type enzyme). It also inhibits LRRK2 containing a glycine-to-serine substitution at position 2019 (LRRK2G2019S, IC50 = 36 nM).. Solulibility: DMSO: Slightly soluble: 0.1-1 mg/ml: .
| Schlagworte: | 5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidine |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1527473-30-8 |
| MW: | 284.32 D |
ab 142,00 €
GSK2578215A
Artikelnummer: Cay14603-5
GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC50 = 10.1 nM). It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type and G2019S LRRK2 in mouse spleen and...
| Schlagworte: | 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-benzamide |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1285515-21-0 |
| MW: | 399.4 D |
ab 85,00 €
MLi-2
Artikelnummer: Cay19305-1
MLi-2 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 0.76 nM). It is greater than 100-fold selective for LRRK2 over a panel of 308 protein kinases, as well as a panel of receptors and ion channels, at 10 µM. It increases glucocerebrosidase (GCase) activity in dopaminergic neurons differentiated from...
| Schlagworte: | rel-3-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1627091-47-7 |
| MW: | 379.5 D |
ab 73,00 €
GNE-0877
Artikelnummer: Cay16251-1
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been...
| Schlagworte: | alpha,alpha,3-trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1374828-69-9 |
| MW: | 339.3 D |
ab 85,00 €
GNE-7915
Artikelnummer: Cay16252-5
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been...
| Schlagworte: | [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-methanone |
| Anwendung: | LRRK2 kinase inhibitor |
| CAS | 1351761-44-8 |
| MW: | 443.4 D |
ab 139,00 €
LRRK2-IN-1
Artikelnummer: Cay18094-10
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been...
| Schlagworte: | Leucine-rich repeat kinase 2 IN-1, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)- 1-piperidinyl]carbonyl]... |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1234480-84-2 |
| MW: | 570.7 D |
ab 50,00 €
HG-10-102-01
Artikelnummer: Cay20049-1
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant...
| Schlagworte: | [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1351758-81-0 |
| MW: | 377.8 D |
ab 50,00 €
JH-II-127
Artikelnummer: Cay22905-5
JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with...
| Schlagworte: | [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1700693-08-8 |
| MW: | 416.9 D |
ab 49,00 €
CZC-25146
Artikelnummer: Cay22931-1
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson's disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell...
| Schlagworte: | N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1191911-26-8 |
| MW: | 488.5 D |
ab 49,00 €
GNE-9605
Artikelnummer: Cay23446-1
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 µM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice...
| Schlagworte: | rel-N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyri... |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1536200-31-3 |
| MW: | 449.8 D |
ab 60,00 €