Anti-LIM Kinase

Anti-LIM Kinase
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
600-401-855 100 µg - -

6 - 10 Werktage*

684,00 €
 
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation... mehr
Produktinformationen "Anti-LIM Kinase"
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. [The UniProt Consortium]
Schlagworte: Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 600-401-855

Eigenschaften

Anwendung: ELISA, IFM, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: synthetic peptide corresponding to amino acids 630-647 of human LIM kinase protein
MW: 73 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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